pentobarbital will enhance the stage or result of ivosidenib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Stay away from or Use Alternate Drug. Coadministration of ivosidenib with powerful CYP3A4 inducers decreased ivosidenib plasma concentrations.pentobarbital decreases amounts of elvitegravir/cobicistat/emtricitabine/tenofovir DF by